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Natural products as leads for tuberculosis drug development
Christine E Salomon1, Lori E Schmidt
1Center for Drug Design, University of Minnesota, Minneapolis MN 55455, USA. csalomon@umn.edu
Current Topics in Medicinal Chemistry
|January 31, 2012
Summary
Natural products offer promising new drug leads for combating drug-resistant tuberculosis and other mycobacterial diseases. This review covers anti-mycobacterial compounds from 2006-2009, including structure-activity relationships.
Area of Science:
- Medicinal Chemistry
- Microbiology
- Natural Products Chemistry
Background:
- Tuberculosis (TB) and related mycobacterial diseases pose a significant global health burden.
- The rise of multi-drug resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains necessitates novel therapeutic strategies.
- Natural products have historically been a rich source of antimicrobial drug leads.
Purpose of the Study:
- To review natural products and synthetic analogues with anti-mycobacterial activity published between 2006 and 2009.
- To summarize structure-activity relationships (SAR) for these compounds.
- To highlight newly reported activities of known anti-mycobacterial agents.
Main Methods:
- Comprehensive literature search of scientific databases for relevant publications from 2006-2009.
- Analysis and synthesis of reported anti-mycobacterial activities of natural products and their analogues.
- Evaluation of structure-activity relationships and novel findings.
Main Results:
- Identification of numerous natural products and synthetic analogues exhibiting anti-mycobacterial activity.
- Detailed SAR studies for several compound classes, guiding further drug development.
- Documentation of updated or newly discovered activities for established anti-mycobacterial natural products.
Conclusions:
- Natural products and their derivatives remain a vital resource for developing new treatments against drug-resistant mycobacterial infections.
- Continued research into natural product chemistry and SAR is crucial for addressing the challenge of MDR-TB and XDR-TB.
- The reviewed period (2006-2009) yielded significant advancements in identifying and characterizing potential anti-mycobacterial agents.
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