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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Introduction Cardiac Emergencies01:30

Introduction Cardiac Emergencies

Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...

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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Ischemic stroke: emergencies and management.

Roger E Kelley1, Sheryl Martin-Schild

  • 1Department of Neurology, Tulane University School of Medicine, 1430 Tulane Avenue 8065, New Orleans, LA 70112, USA. rkelley2@tulane.edu

Neurologic Clinics
|January 31, 2012
PubMed
Summary
This summary is machine-generated.

Acute ischemic stroke management has advanced significantly over 40 years, moving from unproven treatments to evidence-based strategies. Improved stroke imaging and clinical trials now guide effective acute care decisions.

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Published on: January 15, 2017

Area of Science:

  • Neurology
  • Emergency Medicine
  • Clinical Trials

Background:

  • Acute ischemic stroke management has evolved over the past four decades.
  • Early management relied on unproven therapies like steroids and hypervolemic-hemodilution.
  • A shift towards a scientific basis for decision-making is evident.

Purpose of the Study:

  • To review the evolution of acute ischemic stroke management.
  • To highlight the impact of advancements in stroke imaging and clinical trials.
  • To discuss the recognition of thrombolytic therapy benefits and the challenges with neuroprotective agents.

Main Methods:

  • Review of historical management strategies for acute ischemic stroke.
  • Analysis of the role of neuroimaging in stroke care evolution.
  • Examination of outcomes from controlled clinical trials of therapeutic interventions.

Main Results:

  • Management has transitioned from empirical treatments to scientifically validated approaches.
  • Advancements in stroke imaging have been crucial to this evolution.
  • Clinical trials confirmed benefits of thrombolytic therapy but showed limited efficacy for many neuroprotective agents.

Conclusions:

  • Modern acute ischemic stroke management is evidence-based, driven by imaging and clinical trials.
  • Thrombolytic therapy is a cornerstone of acute stroke treatment.
  • Further research is needed to address the lack of efficacy for promising neuroprotective agents.