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Silicon transfer during haemodialysis.

S Hosokawa1, O Yoshida

  • 1Utano National Hospital, Kyoto, Japan.

International Urology and Nephrology
|January 1, 1990
PubMed
Summary
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Silicon levels increase during hemodialysis (HD) due to fluid shifts and leaching from dialysis equipment. This study examined silicon transfer in chronic HD patients to understand these changes.

Area of Science:

  • Nephrology
  • Biochemistry
  • Materials Science

Background:

  • Chronic kidney disease patients undergoing hemodialysis (HD) may experience altered mineral levels.
  • Silicon (Si) is present in dialysis equipment and its transfer during HD is not fully understood.

Purpose of the Study:

  • To investigate silicon transfer and serum Si level changes in patients undergoing chronic hemodialysis.
  • To identify potential sources of silicon increase during the dialysis procedure.

Main Methods:

  • Studied 120 chronic HD patients undergoing 5-hour dialyses thrice weekly.
  • Measured serum and ultrafiltrable silicon (Si) levels using flameless atomic absorption spectrophotometry.
  • Analyzed changes in Si levels in relation to total protein values.

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Main Results:

  • Ultrafiltrable Si levels were found to be approximately equal to dialysate Si levels.
  • Serum Si levels significantly increased in all patients before and during HD.
  • Elevated total protein values were observed concurrently with increased Si levels.

Conclusions:

  • The increase in serum Si levels during HD with cellulose acetate or cuprophan membranes is attributed to hemoconcentration.
  • Liberation of silicon from silicon rubber tubing used in the dialysis circuit is a significant contributing factor to elevated Si levels.