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Chitosan films: crosslinking with EDTA modifies physicochemical and mechanical properties
Kuldeep Singh1, Rajat Suri, A K Tiwary
1Pharmaceutics Division, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India.
Journal of Materials Science. Materials in Medicine
|January 31, 2012
Summary
Chitosan-EDTA films with equal proportions exhibit optimal properties for drug delivery. These films show reduced swelling and permeation, indicating potential for controlled and sustained release pharmaceutical applications.
Area of Science:
- Materials Science
- Polymer Chemistry
- Pharmaceutical Sciences
Background:
- Chitosan films are widely explored for drug delivery due to their biocompatibility.
- Crosslinking agents are crucial for tuning film properties like swelling and drug permeation.
- Ethylenediaminetetraacetic acid (EDTA) is investigated as a potential crosslinker for chitosan.
Purpose of the Study:
- To develop and characterize chitosan-EDTA (CH–EDTA) films.
- To evaluate the impact of CH:EDTA ratio on physico-chemical and mechanical properties.
- To assess the potential of CH–EDTA films for pharmaceutical applications, particularly drug delivery systems.
Main Methods:
- Film preparation using varying ratios of chitosan and EDTA.
- Physical property evaluation: swelling, volume, contact angle, and spreading coefficient.
- Chemical and thermal analysis: Fourier-transform infrared spectroscopy (FTIR) and Differential scanning calorimetry (DSC).
- Mechanical property assessment using a texture analyzer.
- In vitro drug permeation studies using 5-fluorouracil (5-FU) and mesalamine.
Main Results:
- Films prepared with a 1:1 ratio of chitosan to EDTA (CH–EDTA) exhibited lowest swelling and volume.
- The 1:1 CH–EDTA film demonstrated lipophilic behavior with minimum contact angle and work of adhesion.
- FTIR and DSC analysis indicated maximum crosslinking density in the 1:1 CH–EDTA film.
- Increased EDTA proportion led to more flexible and less hard films.
- The 1:1 CH–EDTA film showed minimum in vitro permeation of 5-FU and mesalamine, attributed to high crosslinking density.
Conclusions:
- The 1:1 CH–EDTA film possesses optimal physico-chemical and mechanical properties.
- High crosslinking density in the 1:1 CH–EDTA film effectively reduces void spaces and drug permeation.
- CH–EDTA conjugates show significant potential for developing advanced pharmaceutical film-based delivery systems, including controlled and sustained release formulations.
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