[CRF-BP and SLC6A4 gene polymorphisms among restrained eaters]
Jorge A Sanhueza1, Christian L Herrera, Luis A Salazar
1Programa de Magíster en Ciencias Mención Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile.
Background:
Restrained eaters (RE) are a group of individuals who constantly restrict their eating. However, they usually alternate restriction with periods of overeating.
Aim:
To evaluate the possible association of CRF-BP and SLC6A4 gene polymorphisms with chronic alimentary restriction.
Material And Methods:
The Spanish version of the Revised Restraint Scale was applied to 132 women aged 18 to 25 years. They were divided in a group classified as restrained eaters (RE) and a group of unrestrained eaters. The 5-HTTLPR and CRF-BPs11 polymorphisms of the SLC6A4 and CRF-BP genes were evaluated by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP), respectively.
Results:
There was a significant association between the s/s homozygous genotype for the 5-HTTLPR polymorphism of SLC6A4 gene and RE condition (p = 0.033). However, this association was not observed for the CRF-BPs11 polymorphism.
Conclusions:
The presence of s/s genotype is associated with the RE condition, being the presence of a s allele, a risk factor for this condition.
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