Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Maintenance of the ES Cell State

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...

Zygotic Development And Stem Cell Formation

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Male Factor Infertility Diagnoses, But Not Male Age, Significantly Affects the Yield of Usable Embryos in Donor Oocyte Cycles.

Fertility and sterility·2026

Same author

Association Between Post-Trigger Hormones and <i>In Vitro</i> Fertilization Cycle Outcomes.

Journal of clinical gynecology and obstetrics·2026

Same author

Obesity Epidemic and Its Impact on Female Fertility: Current Understanding and Future Directions.

Cureus·2025

Same author

Age does not affect maximal endometrial thickness achieved in frozen embryo transfer cycles: a SARTCORS study.

Reproductive biology and endocrinology : RB&E·2025

Same author

Dynamic expression of endometrial adhesion G protein-coupled receptors during the menstrual cycle and early mouse pregnancy: modulation by ovarian stimulation.

F&S science·2025

Same author

The impact of ovarian stimulation on the human endometrial microenvironment.

Human reproduction (Oxford, England)·2024

Search research articles

Related Experiment Video

Updated: May 25, 2026

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Published on: May 23, 2014

Endometrial stem cells and reproduction.

Sara S Morelli¹, Pauline Yi, Laura T Goldsmith

¹Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA.

Obstetrics and Gynecology International

|January 31, 2012

Summary

Understanding endometrial stem cells is key to treating infertility. This review introduces new concepts in endometrial stem cell biology for reproductive health.

More Related Videos

Establishing 3D Endometrial Organoids from the Mouse Uterus

Establishing 3D Endometrial Organoids from the Mouse Uterus

Published on: January 6, 2023

Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization

Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization

Published on: September 1, 2018

Related Experiment Videos

Last Updated: May 25, 2026

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Published on: May 23, 2014

Establishing 3D Endometrial Organoids from the Mouse Uterus

Establishing 3D Endometrial Organoids from the Mouse Uterus

Published on: January 6, 2023

Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization

Isolation of Human Endometrial Stromal Cells for In Vitro Decidualization

Published on: September 1, 2018

Area of Science:

Reproductive Biology
Cell Biology
Gynecology

Background:

Abnormal endometrial function contributes to female infertility, implantation failure, and pregnancy loss.
Understanding endometrial cell biology, particularly stem cells, is crucial for developing new infertility treatments.

Purpose of the Study:

To review recent advancements in endometrial stem cell biology.
To highlight the role of endometrial stem cells in reproduction and endometrial regeneration.

Main Methods:

Literature review of current research on endometrial stem cells.
Synthesis of recent findings on endometrial stem cell function and characteristics.

Main Results:

The human endometrium possesses remarkable regenerative capacity, likely mediated by stem cells.
Endometrial stem cells are integral to reproductive success and endometrial repair.

Conclusions:

Novel therapies for infertility require a deeper understanding of endometrial stem cell biology.
Further research into endometrial stem cells offers promising avenues for treating reproductive pathologies.