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Fibril-associated Collagen

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Related Experiment Video

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Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
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Published on: January 31, 2014

Collagen cross-linking: current status and future directions.

Marine Hovakimyan1, Rudolf F Guthoff, Oliver Stachs

  • 1Department of Ophthalmology, University of Rostock, Doberaner Strasse 140, 18057 Rostock, Germany.

Journal of Ophthalmology
|January 31, 2012
PubMed
Summary

Corneal collagen cross-linking (CXL) with UVA light and riboflavin stabilizes the cornea, effectively treating conditions like keratoconus and post-LASIK ectasia. This minimally invasive procedure shows promise for various corneal issues, reducing the need for transplants.

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Preparation of 3D Collagen Gels and Microchannels for the Study of 3D Interactions In Vivo

Published on: May 9, 2016

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Medical Engineering

Background:

  • Corneal ectasia, including keratoconus and post-LASIK ectasia, presents a significant challenge in ophthalmology.
  • Current treatments often involve invasive procedures like corneal transplantation.
  • Collagen cross-linking (CXL) emerged as a novel approach to enhance corneal biomechanical strength.

Purpose of the Study:

  • To review the current understanding and clinical applications of corneal collagen cross-linking (CXL).
  • To summarize the efficacy and safety of CXL for various corneal conditions.
  • To highlight CXL as a potential alternative to penetrating keratoplasty.

Main Methods:

  • Systematic review of recent literature on corneal collagen cross-linking.
  • Analysis of clinical studies investigating CXL for keratoconus, post-LASIK ectasia, corneal edema, and keratitis.
  • Evaluation of CXL's biomechanical effects on corneal collagen fibers.

Main Results:

  • CXL has demonstrated clinical success in arresting the progression of keratoconus and post-LASIK ectasia.
  • Evidence suggests CXL benefits corneal edema by reducing stromal swelling.
  • CXL shows potential in managing keratitis by inhibiting pathogen growth.

Conclusions:

  • Corneal collagen cross-linking is a promising, cost-effective, and minimally invasive treatment for corneal ectasia.
  • Further research is needed to fully elucidate potential side effects and recurrence rates associated with CXL.
  • CXL may significantly reduce the reliance on penetrating keratoplasty for specific corneal pathologies.