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Published on: January 2, 2012
[Macro- and microscopic systematization of cerebral cortex malformations in children]
Insights
This study presents the first comprehensive classification of cerebral cortex malformations in pediatric pathology. It details macroscopic forms and microscopic subtypes, aiding in diagnosis and understanding of these developmental brain abnormalities.
Area of Science:
- Neuropathology
- Pediatric Pathology
- Developmental Neuroscience
Abstract:
For the first time in pediatric pathologicoanatomic practice the complete systematization of cerebral cortex malformations is represented. Organ, macroscopic forms: microencephaly, macroencephaly, micropolygyria, pachygyria, schizencephaly, porencephaly, lissencephaly. Histic microdysgenesis of cortex: type I includes isolated abnormalities such as radial (IA) and tangential (I B) subtypes of cortical dislamination; type II includes sublocal cortical dislamination with immature dysmorphic neurons (II A) and balloon cells (II B); type III are the combination focal cortical dysplasia with tuberous sclerosis of the hippocampus (III A), tumors (III B) and malformations of vessels, traumatic and hypoxic disorders (III C). Band heterotopias. Subependimal nodular heterotopias. Tuberous sclerosis. Cellular typification of cortical dysplasia: immature neurons and balloon cells.
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