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Updated: May 25, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
[Current strategies for treatment of alcohol problems]
Henri-Jean Aubin1, Amine Benyamina, Laurent Karila
1Hôpital Paul Brousse, addictologie, 94804 Villejuif Cedex. henri-jean.aubin@pbr.aphp.fr
Abstract:
Amongst validated psychological treatments, brief intervention appears to be the best suited for primary care. It aims at increasing motivation for change after a screening for an alcohol use disorder. The first therapeutic step for an alcohol-dependent patient aiming at abstinence is alcohol detoxification. At this stage, benzodiazepines should be briefly prescribed if the patient manifests clinically significant withdrawal symptoms. The next step is relapse prevention, for which only three medications are currently validated in France, acamprosate, naltrexone, and disulfiram.
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