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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
[Vitamin D intake in young children with acute lower respiratory infection]
Karen S Leis1, J Dayre McNally, Matthew R Montgomery
1Department of Pediatrics, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. karen.leis@usask.ca
Insights
Children with lower vitamin D intake were significantly more likely to experience acute lower respiratory infections (ALRI). Increased vitamin D supplementation may be crucial for preventing common childhood illnesses like bronchiolitis and pneumonia.
Area of Science:
- Pediatrics
- Nutritional Science
- Infectious Disease Epidemiology
Context:
- Acute lower respiratory infections (ALRI) are a leading cause of hospitalization in children under five.
- Vitamin D's role in immune function is increasingly recognized, but its specific impact on pediatric ALRI requires further elucidation.
Purpose:
- To investigate the association between vitamin D intake and the incidence of acute lower respiratory infections (ALRI) in young children.
- To compare vitamin D consumption in hospitalized children with ALRI versus a healthy control group.
Summary:
- A study involving 197 children under five found that those with ALRI had a mean vitamin D intake of 48 IU/kg/d, compared to 60 IU/kg/d in controls.
- After adjusting for confounding factors, children with vitamin D intake below 80 IU/kg/d were over four times more likely to have ALRI (OR=4.9).
Impact:
- Findings suggest current vitamin D recommendations may be insufficient for protecting children against ALRI.
- Increased vitamin D supplementation could represent a significant public health strategy to reduce pediatric hospitalizations for pneumonia and bronchiolitis.
Objective:
To determine if vitamin D intake is associated with acute lower respiratory infections (ALRI) in children.
Methods:
The vitamin D intakes of children younger than 5 years of age admitted to hospital with either bronchiolitis or pneumonia were compared to an unmatched control group of the same age without respiratory infection. Caregivers of 197 children completed a questionnaire collecting information on demographic variables, ALRI risk factors and diet. Associations of ALRI with vitamin D intake and other ALRI risk factors were determined.
Results:
The mean vitamin D intake of children with ALRI was 48 IU/kg/d compared to 60 IU/kg/d in the control group. When controlling for age, ethnicity, socio-economic status, northern residence, breastfeeding, immunizations and smoking contact, children with a vitamin D intake of less than 80 IU/kg/d were greater than 4 times more likely to have ALRI compared to children with a vitamin D intake exceeding 80 IU/kg/d (OR=4.9; 95%CI: 1.5-16.4).
Conclusions:
A higher vitamin D intake than currently recommended might be needed to offer protection against diseases such as ALRI. Increased vitamin D supplementation could have important public health consequences, as bronchiolitis and pneumonia are the most common reasons for hospitalization in young children. (Full English version will be available online at www.amepc.org/tp.).
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