[Vitamin D intake in young children with acute lower respiratory infection]

Karen S Leis1, J Dayre McNally, Matthew R Montgomery

  • 1Department of Pediatrics, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. karen.leis@usask.ca

Insights

Children with lower vitamin D intake were significantly more likely to experience acute lower respiratory infections (ALRI). Increased vitamin D supplementation may be crucial for preventing common childhood illnesses like bronchiolitis and pneumonia.

Area of Science:

  • Pediatrics
  • Nutritional Science
  • Infectious Disease Epidemiology

Context:

  • Acute lower respiratory infections (ALRI) are a leading cause of hospitalization in children under five.
  • Vitamin D's role in immune function is increasingly recognized, but its specific impact on pediatric ALRI requires further elucidation.

Purpose:

  • To investigate the association between vitamin D intake and the incidence of acute lower respiratory infections (ALRI) in young children.
  • To compare vitamin D consumption in hospitalized children with ALRI versus a healthy control group.

Summary:

  • A study involving 197 children under five found that those with ALRI had a mean vitamin D intake of 48 IU/kg/d, compared to 60 IU/kg/d in controls.
  • After adjusting for confounding factors, children with vitamin D intake below 80 IU/kg/d were over four times more likely to have ALRI (OR=4.9).

Impact:

  • Findings suggest current vitamin D recommendations may be insufficient for protecting children against ALRI.
  • Increased vitamin D supplementation could represent a significant public health strategy to reduce pediatric hospitalizations for pneumonia and bronchiolitis.
Abstract

Related Concept Videos

Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Acute Pharyngitis01:30

Acute Pharyngitis

Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...