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Updated: May 25, 2026
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
[Obesity and colorectal cancer]
Soo-Young Na1, Seung-Jae Myung
1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi
|February 1, 2012
Summary
Obesity significantly increases colorectal cancer risk by 1.5 times, particularly in men and colon cancer. Lifestyle changes may reduce this risk, highlighting obesity as a modifiable factor.
Area of Science:
- Oncology
- Metabolic Syndrome
Context:
- Rising global obesity rates present a significant public health challenge.
- Obesity is an independent risk factor for various cancers, including colorectal cancer (CRC).
- Visceral adipose tissue plays a more critical role than subcutaneous adipose tissue in metabolic processes.
Purpose:
- To review the association between obesity and colorectal cancer incidence, progression, and outcomes.
- To explore the underlying mechanisms linking obesity to colorectal carcinogenesis.
- To discuss the potential impact of weight management on CRC risk and patient prognosis.
Summary:
- Obese individuals have a 1.5-fold higher relative risk of CRC, with higher incidence in men and colon compared to rectum.
- Mechanisms include altered levels of insulin, insulin-like growth factor, leptin, adiponectin, chronic inflammation, and gut microbiome changes.
- Obesity negatively impacts CRC progression and chemotherapy response.
Impact:
- Obesity is identified as a significant, modifiable risk factor for colorectal cancer.
- Understanding these links can inform targeted prevention and treatment strategies.
- Weight loss and lifestyle modifications show potential in reducing CRC risk and improving outcomes.
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