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Updated: May 25, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
The isolation of a new S-methyl benzothioate compound from a marine-derived Streptomyces sp
Nor Ainy Mahyudin1, John W Blunt, Anthony L J Cole
1Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Serdang, Malaysia. norainy@food.upm.edu.my
Abstract:
The application of an HPLC bioactivity profiling/microtiter plate technique in conjunction with microprobe NMR instrumentation and access to the AntiMarin database has led to the isolation of a new 1. In this example, 1 was isolated from a cytotoxic fraction of an extract obtained from marine-derived Streptomyces sp. cultured on Starch Casein Agar (SCA) medium. The 1D and 2D (1)H NMR and ESIMS data obtained from 20 μg of compound 1 fully defined the structure. The known 2 was also isolated and readily dereplicated using this approach.
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