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Updated: May 25, 2026

In vitro Measurements of Tracheal Constriction Using Mice
Published on: June 25, 2012
Cholinergic regulation of airway inflammation and remodelling
Saeed Kolahian1, Reinoud Gosens
1Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Iran.
Abstract:
Acetylcholine is the predominant parasympathetic neurotransmitter in the airways that regulates bronchoconstriction and mucus secretion. Recent findings suggest that acetylcholine regulates additional functions in the airways, including inflammation and remodelling during inflammatory airway diseases. Moreover, it has become apparent that acetylcholine is synthesized by nonneuronal cells and tissues, including inflammatory cells and structural cells. In this paper, we will discuss the regulatory role of acetylcholine in inflammation and remodelling in which we will focus on the role of the airway smooth muscle cell as a target cell for acetylcholine that modulates inflammation and remodelling during respiratory diseases such as asthma and COPD.
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