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Updated: May 25, 2026
13:19
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
The lady with raised prostate specific antigen: do we need to worry?
Soumen Das1, Retina Paul, Utpal De
1Department of Surgery, Ipgmer and SSKM Hospital, Kolkata, India. drsoumen_das@yahoo.co.in
Asian Pacific Journal of Cancer Prevention : APJCP
|February 2, 2012
Summary
Prostate-specific antigen (PSA) can indicate breast diseases in women. Elevated total PSA levels are linked to benign breast disease, while free PSA increases are associated with breast cancer, aiding in secondary prevention.
Area of Science:
- Oncology
- Biochemistry
- Women's Health
Background:
- Prostate-specific antigen (PSA) is a known marker for prostate cancer, but can be elevated in benign prostatic conditions.
- PSA is also produced at low levels in women by Skeine's periurethral glands.
- The relationship between PSA and various diseases in women requires further investigation.
Purpose of the Study:
- To evaluate the association between Prostate-specific antigen (PSA) levels and breast diseases in women.
- To determine if PSA can serve as a diagnostic marker for breast cancer in the female population.
Main Methods:
- A case-control study involving 297 female participants.
- Participants included 107 with breast cancer, 90 with benign breast disease (BBD), and 100 controls.
- Serum PSA levels were measured and statistically analyzed.
Main Results:
- A significant association was found between elevated PSA levels and breast diseases.
- Total PSA was more sensitive in detecting benign breast diseases.
- Increased free PSA levels showed a predilection for breast cancer, with PSA levels decreasing post-surgery.
Conclusions:
- Prostate-specific antigen (PSA) demonstrates potential as a diagnostic and prognostic marker for breast cancer in women.
- Utilizing PSA could enhance the secondary prevention strategies for breast cancer.
- Further research into PSA's role in women's health is warranted.
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