Related Experiment Video
Updated: May 25, 2026
07:34
Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
Collagenous colitis-like condition in immunosuppressed infant baboons
Eefje M Dons1, Gabriel J Echeverri, Lora H Rigatti
1Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Inflammatory Bowel Diseases
|February 2, 2012
Summary
Collagenous colitis, a rare infant inflammatory bowel disease, was observed in four immunosuppressed baboons. Treatment with budesonide led to recovery, suggesting an association with compromised immunity and potential infectious origins.
Area of Science:
- Veterinary Medicine
- Gastroenterology
- Immunology
Background:
- Collagenous colitis is a chronic inflammatory bowel disease with unknown causes, rare in infants, and linked to autoimmune conditions.
- This study investigates collagenous colitis in infant baboons, a species where it has been previously reported only once.
Purpose of the Study:
- To report and analyze cases of collagenous colitis in infant baboons following organ transplantation and immunosuppressive therapy.
- To compare the clinical and histopathological features of collagenous colitis in baboons to those in human patients.
Main Methods:
- Four infant baboons (7-12 months) received transplants and immunosuppression for 4-10 months.
- All baboons presented with weight loss and chronic watery diarrhea unresponsive to antimicrobial treatment.
- Diagnostic workup included clinical chemistry, viral testing, and microbial cultures; necropsy was performed on two baboons.
Main Results:
- Standard diagnostic tests were inconclusive, ruling out common infections.
- Two baboons were diagnosed with collagenous colitis post-necropsy.
- The other two baboons recovered after discontinuing immunosuppression and initiating budesonide treatment, remaining healthy for 24 months.
Conclusions:
- Clinical and histopathological findings in baboons closely resemble human collagenous colitis.
- The condition in baboons was associated with their immunocompromised state.
- The rapid onset in all four cases suggests a possible infectious etiology.
Related Concept Videos
01:25Immunodeficiency Diseases
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
There are three main causes of immunodeficiency disorders...
01:20Inflammatory Bowel Disease II: Ulcerative Colitis
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
01:15Transcytosis of IgG
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...