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Drug delivery systems. 4. Implants in drug delivery
1Action Medical Marketing Co. Libertyville, Illinois.
Journal of Clinical Pharmacology
|October 1, 1990
Summary
Implantable drug delivery pumps are complex and not yet routine. Osmotic pump systems offer controlled release and reduced dosing frequency, particularly for insulin delivery.
Area of Science:
- Biomedical Engineering
- Pharmaceutics
- Drug Delivery Systems
Background:
- Implantable pumps for variable rate drug delivery are in early development stages.
- Current systems are complex, prone to failure, and lack user convenience.
- Challenges include reservoir refilling and unestablished transcutaneous energy systems.
Purpose of the Study:
- To review the characteristics of ideal implantable pumps.
- To identify clinical situations necessitating pump use.
- To analyze limitations of portable pumps and existing implantable devices, with a focus on insulin delivery.
Main Methods:
- Literature review of implantable pump technology and drug delivery systems.
- Analysis of physical-chemical formulation and clinical testing pathways for osmotic pumps.
- Evaluation of pharmacokinetic and pharmacodynamic benefits of rate-controlled release.
Main Results:
- Implantable pumps currently face significant mechanical and electrical reliability issues.
- Osmotic pump systems demonstrate potential for zero-order drug release and reduced administration frequency.
- Successful implementation requires quantifiable pharmacokinetic and pharmacodynamic data.
Conclusions:
- Further development is needed to improve the reliability and usability of implantable drug delivery pumps.
- Osmotic and other rate-controlled dosage forms are crucial for future pharmaceutical products.
- Insulin delivery via implantable pumps remains a key area of focus due to its clinical importance.
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