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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Axillary lymph node dissection for malignant melanoma.

Paul G Davis1, Jonathan W Serpell, John W Kelly

  • 1Department of General Surgery, The Alfred Hospital, Australia. p.g.davis@hotmail.com

ANZ Journal of Surgery
|February 3, 2012
PubMed
Summary
This summary is machine-generated.

Axillary lymph node dissections (ALND) for malignant melanoma carry a high risk of complications and local recurrences (LRs). Primary abdominal melanoma is a significant risk factor for LRs after ALND.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Dermatology

Background:

  • Malignant melanoma frequently metastasizes to lymph nodes, often requiring axillary lymph node dissections (ALND) for regional control.
  • ALND can lead to significant morbidity and local recurrences (LRs) in the surgical area.
  • Understanding LR and complication rates, along with risk factors, is crucial for managing melanoma patients.

Purpose of the Study:

  • To determine the rate of local recurrence (LR) and post-operative complications following axillary lymph node dissection (ALND) for malignant melanoma.
  • To identify risk factors associated with both local recurrence and complications after ALND.

Main Methods:

  • Retrospective analysis of 74 patients who underwent ALND between 1999 and 2008.
  • Data collected from the Victorian Melanoma Service database, prospectively kept patient demographics, and histopathological reports.
  • Review of clinical notes and histopathological reports for operative and post-operative information.

Main Results:

  • 16% of patients developed local recurrence (LR) with a median follow-up of 9.5 months.
  • 46% of patients experienced post-operative complications.
  • Primary melanoma on the abdomen significantly increased LR risk (Hazard ratio 3.84; P = 0.048).

Conclusions:

  • Axillary lymph node dissection (ALND) is linked to substantial post-operative complications.
  • While ALND aids regional disease control, a significant risk of local recurrence (LR) persists.
  • Local recurrence after ALND portends a poor prognosis for malignant melanoma patients.