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Updated: May 25, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Two new compounds from Dictamnus dasycarpus
Li-Na Guo1, Yue-Hu Pei, Gang Chen
1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China. gln65@126.com
Abstract:
Two new compounds, one new pyrrolidine alkaloid and one new eudesmane-type sesquiterpene derivative, named, respectively, as dictamnaindiol and dictamnadiol, were isolated from the EtOAc soluble fraction of the ethanolic extract from the root barks of Dictamnus dasycarpus. Their structures were elucidated as (3α,4β)-3-(6-ethoxy-6-(4-hydroxyphenyl)methyl)-4-(4-hydroxyphenyl)-1-methyl-pyrrolidin-2-one (1) and (1R, 4S, 7S, 10R)-1,11-dihydroxyl-4,14-epoxy-5(6)-eudesmene (2) on the basis of their spectral and chemical analysis.
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Structure of Conjugated Dienes
Conjugated dienes are compounds characterized by the presence of alternating double and single bonds. In a conjugated system like 1,3-butadiene, the unhybridized 2p orbital on each carbon overlaps continuously, allowing the π electrons to be delocalized across the entire molecule. In contrast, this type of overlap does not occur in cumulated and isolated dienes, such as 2,3-pentadiene and 1,4-pentadiene, respectively. Instead, the π electrons remain localized between the double...
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Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable, the...