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Surface microdialysis sampling: a new approach described in a liver ischaemia model
Pernilla Abrahamsson1, Anna-Maja Aberg, Ola Winsö
1Department of Surgical and Perioperative Sciences, Umeå University Hospital, Umeå, Sweden. pernilla.abrahamsson@anestesi.umu.se
Clinical Physiology and Functional Imaging
|February 3, 2012
Summary
Microdialysis (MD) probes on the liver surface accurately reflect metabolic changes, similar to probes within the liver parenchyma. This finding validates surface MD for monitoring liver metabolism during various conditions.
Area of Science:
- Physiology
- Metabolic Monitoring
- Surgical Techniques
Background:
- Previous studies demonstrated microdialysis (MD) probes on the heart surface reflect myocardial metabolic events.
- The efficacy of surface MD application on other parenchymatous organs remained unexplored.
Purpose of the Study:
- To investigate the feasibility of using surface microdialysis (MD) probes to monitor liver metabolism.
- To compare metabolic analyte levels obtained from liver surface MD probes with those from intraparenchymal probes.
Main Methods:
- Transient liver ischemia was induced in anesthetized pigs.
- Microdialysis probes were placed on the liver surface and within the liver parenchyma.
- Lactate, glucose, pyruvate, and glycerol levels were analyzed during baseline, ischemia, and reperfusion.
Main Results:
- A strong agreement was observed in relative lactate and glucose levels between surface and parenchymal MD probes.
- No significant differences in relative metabolic changes were detected between surface and parenchymal probes at a 1 μl/min flow rate.
- The study confirmed reliable metabolic monitoring via surface MD during physiological and pathophysiological states.
Conclusions:
- Surface microdialysis (MD) is a viable method for monitoring liver metabolism.
- This technique offers a new application for MD in assessing liver function.
- Surface MD can be utilized in both physiological and pathological liver conditions.
