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Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

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Irritable bowel syndrome.

Alexander Charles Ford1, Per Olav Vandvik

  • 1Leeds Gastroenterology Institute, St James's University Hospital, Leeds, UK.

BMJ Clinical Evidence
|February 3, 2012
PubMed
Summary
This summary is machine-generated.

This systematic review examines treatments for irritable bowel syndrome (IBS), finding evidence for various interventions like medications and therapies. It assesses the effectiveness and safety of these IBS treatments.

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Area of Science:

  • Gastroenterology
  • Pharmacology
  • Psychiatry

Background:

  • Irritable bowel syndrome (IBS) affects 5-20% of the population, linked to gut motility, perception, and psychosocial factors.
  • IBS patients often experience comorbid physical and psychiatric conditions, increasing surgical risks.
  • The condition's diagnosis and prevalence vary based on diagnostic criteria.

Purpose of the Study:

  • To systematically review and evaluate the effects of various treatments for irritable bowel syndrome (IBS).
  • To assess the effectiveness and safety of pharmacological and non-pharmacological interventions for IBS.
  • To synthesize evidence from systematic reviews, RCTs, and observational studies.

Main Methods:

  • Conducted a systematic literature review up to August 2011, searching major databases (Medline, Embase, Cochrane Library).
  • Included studies: systematic reviews, randomized controlled trials (RCTs), and observational studies.
  • Incorporated safety alerts from regulatory agencies (FDA, MHRA) and performed GRADE evaluations.

Main Results:

  • Identified 27 relevant systematic reviews, RCTs, or observational studies meeting inclusion criteria.
  • Evaluated the quality of evidence for different IBS interventions using the GRADE system.
  • The review covers a range of treatments including 5HT receptor antagonists/agonists, antidepressants, antispasmodics, CBT, hypnotherapy, loperamide, and fiber supplements.

Conclusions:

  • Presents findings on the effectiveness and safety of multiple IBS interventions.
  • Information covers 5HT(3) receptor antagonists, 5HT(4) receptor agonists, antidepressants (TCAs, SSRIs), antispasmodics (peppermint oil), CBT, hypnotherapy, loperamide, and fiber.
  • The review provides a comprehensive overview of current evidence for IBS treatment options.