Related Experiment Video

Updated: May 25, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

Mean platelet volume in patients with dilated cardiomyopathy: does it have a role in left ventricular thrombus

Gulacan Tekin1, Nasir Sivri, Yusuf Kenan Tekin

  • 1Department of Cardiology, Bozok University Faculty of Medicine, Yozgat, Turkey. gulacantekin@hotmail.com

Angiology
|February 3, 2012
PubMed

Insights

Patients with dilated cardiomyopathy (DCMP) show increased mean platelet volume (MPV), indicating heightened platelet activation. Elevated MPV in DCMP patients with left ventricle (LV) thrombus was similar to those without LV thrombus.

Area of Science:

  • Cardiology
  • Hematology
  • Biochemistry

Background:

  • Dilated cardiomyopathy (DCMP) is a significant cause of heart failure.
  • Left ventricle (LV) thrombus formation is a known complication of DCMP.
  • Platelet activation markers, such as mean platelet volume (MPV), may play a role in DCMP pathophysiology.

Purpose of the Study:

  • To investigate the association between mean platelet volume (MPV) and dilated cardiomyopathy (DCMP).
  • To explore the relationship between MPV and left ventricle (LV) thrombus formation in DCMP patients.

Main Methods:

  • Clinical, echocardiographic, hematological, and biochemical parameters were assessed.
  • A cohort of 251 DCMP patients and 266 control individuals were studied.
  • MPV levels were compared between DCMP patients and controls, and within DCMP patients stratified by the presence of LV thrombus.

Main Results:

  • Mean platelet volume (MPV) was significantly higher in DCMP patients compared to controls (P < .05).
  • DCMP patients with LV thrombus (n=19) exhibited a higher prevalence of smokers and lower ejection fraction compared to those without LV thrombus (n=232).
  • MPV levels in DCMP patients with LV thrombus were comparable to those without LV thrombus.

Conclusions:

  • Elevated MPV in DCMP patients suggests increased platelet activation.
  • While MPV is higher in DCMP, it does not appear to be a differentiating factor for LV thrombus formation within this patient group.

More Related Videos

Microfluidics in Assessing Platelet Function06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...