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Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
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Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
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Updated: May 25, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Antidepressant Use During Breastfeeding.

Jan Øystein Berle1, Olav Spigset

  • 1Department of Psychiatry, Haukeland University Hospital, P.O. Box 23 Sandviken, N-5812 Bergen, Norway.

Current Women'S Health Reviews
|February 3, 2012
PubMed
Summary
This summary is machine-generated.

Breastfeeding mothers with depression can safely use newer antidepressants. Most drugs result in very low infant exposure, making continued breastfeeding a viable option after careful risk-benefit assessment.

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Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
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Related Experiment Videos

Last Updated: May 25, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

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Published on: June 6, 2025

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents
07:30

Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

Published on: June 10, 2013

Area of Science:

  • Pharmacology
  • Neonatal Medicine
  • Psychiatry

Background:

  • Treatment of maternal depression during breastfeeding presents challenges due to potential infant drug exposure via breast milk.
  • This review focuses on newer, non-tricyclic antidepressants for postpartum depression management.

Purpose of the Study:

  • To provide clinicians with practical advice and recommendations for treating postpartum depression in breastfeeding mothers.
  • To review the safety and efficacy of newer antidepressants in the context of breastfeeding.

Main Methods:

  • Conducted an electronic literature search focusing on newer, non-tricyclic antidepressant compounds.
  • Excluded tricyclic antidepressants due to decreased usage and lack of recent breastfeeding data.

Main Results:

  • Most newer antidepressants show very low or undetectable plasma concentrations in nursing infants.
  • Fluoxetine, citalopram, and venlafaxine reported the highest infant plasma levels, with some suspected adverse effects noted.
  • Infant exposure to antidepressants via breast milk is generally low to very low.

Conclusions:

  • Breastfeeding should not be discontinued solely due to the need for antidepressant treatment in mothers with postpartum depression.
  • Paroxetine and sertraline are recommended as suitable first-line agents.
  • Continued breastfeeding may be permissible with fluoxetine, citalopram, or venlafaxine if the mother used them during pregnancy, following an individual risk-benefit analysis.