Related Experiment Video
Updated: May 25, 2026

06:46
Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
[High-resolution manometry of the upper esophageal sphincter]
1Klinik und Poliklinik für Phoniatrie und Pädaudiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
HNO
|February 4, 2012
Summary
A new catheter and software allow detailed analysis of upper esophageal sphincter function during swallowing. This minimally invasive tool aids in diagnosing and planning treatment for swallowing disorders like dysphagia.
Area of Science:
- Gastroenterology
- Physiology
Context:
- High-resolution manometry (HRM) is crucial for esophageal peristalsis evaluation.
- Current HRM methods have limitations in assessing upper esophageal sphincter (UES) relaxation due to transducer spacing.
Purpose:
- To assess the feasibility of evaluating UES behavior during swallowing using a novel catheter with closely spaced pressure transducers.
- To determine if swallow-associated UES dynamics can be verified with this new technology.
Summary:
- A feasibility study utilized a specially developed catheter and modified software with healthy subjects.
- The system successfully interpreted UES pressure profiles, including resting pressure, residual pressure, relaxation time, and maximum peristaltic pressure.
- Analysis revealed distinct dynamic swallow-associated phases, suggesting the addition of a new initial phase.
Impact:
- The new catheter design and software offer a detailed, minimally invasive, and radiation-free method for evaluating UES function.
- This advancement is valuable for diagnosing dysphagia and planning treatment strategies.
Related Concept Videos
Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Gastroesophageal Reflux Disease II: Clinical Features and Management
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Esophageal Achalasia
Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Hiatal Hernia
A hiatal hernia is the abnormal protrusion of the stomach or other abdominal organs through the esophageal hiatus of the diaphragm into the thoracic cavity.Normally, the gastroesophageal junction (GEJ) lies below the diaphragm and is supported by the phrenoesophageal membrane, the diaphragmatic crura, and connective tissues. Weakening of these structures—due to aging, congenital defects like a short esophagus, or increased intra-abdominal pressure from coughing, obesity, pregnancy, or heavy...
Upper GI Series: Barium Swallow
The Barium Swallow Study, or a Barium Esophagogram, is a diagnostic imaging method used to visualize the upper gastrointestinal (GI) tract, including the esophagus, stomach, and small intestine. It employs barium sulfate, a radiopaque contrast material, to provide clear images of the upper digestive system, helping to identify abnormalities, diseases, or structural issues.
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
Esophageal Strictures-II: Clinical Features and Management
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...

