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In vitro Dissolution Studies on Solid Dispersions of Mefenamic Acid.
K R S Sambasiva Rao1, M V Nagabhushanam, K P R Chowdary
1Achrya Nagarjuna University, Nagarjunanagar-522 510, Guntur, India.
Indian Journal of Pharmaceutical Sciences
|February 4, 2012
Summary
Solid dispersions significantly enhance mefenamic acid dissolution. Combining primojel (super disintegrant) and polyvinyl pyrrolidine with mefenamic acid dramatically increased its dissolution rate and efficiency.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Mefenamic acid exhibits poor aqueous solubility, limiting its bioavailability.
- Enhancing the dissolution rate of poorly soluble drugs is crucial for improving therapeutic efficacy.
Purpose of the Study:
- To prepare and characterize solid dispersions of mefenamic acid using polyvinyl pyrrolidine and primojel.
- To evaluate the impact of these solid dispersions on the dissolution rate and efficiency of mefenamic acid.
Main Methods:
- Solid dispersions were prepared using methanol as a solvent via common solvent and solvent evaporation techniques.
- Dissolution studies were conducted comparing pure mefenamic acid with its various solid dispersion formulations.
Main Results:
- Solid dispersions demonstrated a marked enhancement in both dissolution rate and dissolution efficiency compared to pure mefenamic acid.
- A 2.61-fold increase in dissolution rate was observed with a 1:4 ratio of mefenamic acid-primojel.
- A mefenamic acid-primojel-polyvinyl pyrrolidine (1:3.2:0.8) solid dispersion yielded a 4.11-fold increase in dissolution rate.
Conclusions:
- Solid dispersions incorporating super disintegrants like primojel, alone or with polyvinyl pyrrolidine, effectively enhance mefenamic acid's dissolution.
- These formulations offer a promising strategy for improving the bioavailability of mefenamic acid.
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