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All-plastic electrochemical transistor for glucose sensing using a ferrocene mediator
Na Young Shim1, Daniel A Bernards, Daniel J Macaya
1Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.
Sensors (Basel, Switzerland)
|February 4, 2012
Summary
This study presents a novel organic electrochemical transistor (OECT) glucose sensor. The device utilizes a conducting polymer and detects glucose at micromolar levels, suitable for saliva analysis.
Area of Science:
- Materials Science
- Electrochemistry
- Biosensors
Background:
- Organic electrochemical transistors (OECTs) offer potential for miniaturized biosensing applications.
- Conducting polymers like PEDOT:PSS are suitable for fabricating electrodes in OECTs.
- Glucose detection is crucial for various diagnostic and monitoring purposes.
Purpose of the Study:
- To develop and characterize a glucose sensor utilizing an OECT architecture.
- To explore the use of poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonate) (PEDOT:PSS) for all-organic electrodes.
- To evaluate the sensor's performance for glucose detection in relevant biological fluids.
Main Methods:
- Fabrication of an OECT device with PEDOT:PSS for channel, source, drain, and gate electrodes.
- Integration of a ferrocene mediator to facilitate electron transfer between glucose oxidase and the gate electrode.
- Characterization of the OECT's response to varying glucose concentrations.
Main Results:
- The OECT-based glucose sensor demonstrated successful detection of glucose.
- The device achieved glucose detection sensitivity down to the micromolar range.
- The sensor's performance is consistent with glucose levels found in human saliva.
Conclusions:
- A novel, all-organic electrochemical transistor glucose sensor has been successfully demonstrated.
- The developed sensor shows promise for non-invasive glucose monitoring using saliva.
- The use of PEDOT:PSS and a ferrocene mediator enables efficient and sensitive glucose detection.
