Related Experiment Video
Updated: May 25, 2026
07:23
Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
Transcriptional regulation: a genomic overview
The Arabidopsis Book
|February 4, 2012
Summary
The Arabidopsis thaliana genome sequence enables comprehensive plant transcriptional regulation analysis. Over 1,500 transcription factors highlight evolutionary diversity while maintaining conserved eukaryotic principles.
Area of Science:
- Plant genomics
- Molecular biology
- Evolutionary biology
Background:
- The availability of the Arabidopsis thaliana genome sequence provides a foundation for detailed studies of transcriptional regulation.
- Transcription factors are key regulators, with Arabidopsis possessing over 1,500, representing approximately 6% of its genes.
Purpose of the Study:
- To analyze transcriptional regulation in plants using genomic approaches.
- To compare transcription factor diversity across eukaryotic kingdoms and understand evolutionary patterns.
- To outline the necessary components for a global understanding of plant transcription.
Main Methods:
- Genome-wide analysis of transcription factors in Arabidopsis thaliana.
- Comparative genomics across eukaryotic kingdoms.
- Conceptual framework for characterizing the plant transcriptome, promoterome, and proteome.
Main Results:
- Arabidopsis thaliana genome encodes over 1,500 transcription factors.
- Genome-wide comparisons reveal evolutionary diversification of regulatory machinery.
- Plant transcription shares fundamental principles with animals and fungi.
Conclusions:
- The Arabidopsis genome sequence facilitates comprehensive analysis of plant transcriptional regulation.
- Understanding plant transcription requires characterizing the transcriptome, promoterome, interactome, localizome, and phenome.
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Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
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01:17Transcription
Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
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01:10Transcription
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
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