Related Concept Videos
01:29Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
02:35Key Elements for Plant Nutrition
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the atmosphere, the...
01:27Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase
Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
02:02Genomics
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
01:29Pharmacogenetics and Pharmacogenomics: Overview
Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
01:31Transducer Mechanism: Nuclear Receptors
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
You might also read
Related Articles
Articles linked to this work by shared authors, journal, and citation graph.
Sort by
Same author
Applicability of the New Zealand-eating behavior questionnaire to predict weight loss responses to naltrexone/bupropion: a proof-of-concept trial.
Obesity pillars·2025
Same author
Evidence for a Modulatory Effect of a 12-Week Pomegranate Juice Intervention on the Transcriptional Response in Inflammatory Bowel Disease Patients Reducing Fecal Calprotectin Levels: Findings From a Proof-of-Principle Study.
Molecular nutrition & food research·2025
Same author
Assessment of factors associated with PSA level in prostate cancer cases and controls from three geographical regions.
Scientific reports·2022
Same author
Effect of androgen deprivation therapy on serum levels of sclerostin, Dickkopf-1, and osteoprotegerin: a cross-sectional and longitudinal analysis.
Scientific reports·2021
Same author
A Polyphenol Enriched Variety of Apple Alters Circulating Immune Cell Gene Expression and Faecal Microbiota Composition in Healthy Adults: A Randomized Controlled Trial.
Nutrients·2021
Same journal
Potential role of the <i>Trpv4 c.1491+1G>A</i> mutation in pulmonary fibrosis in a gene-edited mouse model.
Frontiers in genetics·2026
Same journal
Utilization of whole exome sequencing to identify hereditary mutations in Palestinian families with hereditary cancers.
Frontiers in genetics·2026
Same journal
Research of N-acetyl-L-cysteine on CD40-CD40L pathway in pulmonary fibrosis induced by silicon dioxide.
Frontiers in genetics·2026
Same journal
Network-based analysis identifies shared mechanisms between ischemic stroke and myocardial infarction and therapeutic ingredients of Buyang Huanwu Decoction.
Frontiers in genetics·2026
Same journal
GWAS analysis of a depression cohort defined by an EHR-phenotyping algorithm reveals the role of immune regulations in depression risk.
Frontiers in genetics·2026
Related Experiment Video
Updated: May 25, 2026
06:21
Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Nutrigenetics, nutrigenomics, and selenium.
Lynnette R Ferguson1, Nishi Karunasinghe
1Discipline of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland Auckland, New Zealand.
Frontiers in Genetics
|February 4, 2012
Summary
Selenium (Se) is vital for health, influencing oxidative and inflammatory processes. Nutrigenomics reveals personalized Se needs based on genetics, requiring large studies for definitive proof of supplementation benefits.
Area of Science:
- Nutritional Science
- Genomics
- Systems Biology
Background:
- Selenium (Se) is an essential micronutrient crucial for selenoprotein function, impacting oxidative and inflammatory responses.
- Optimal Se levels are vital for homeostasis but vary significantly based on life stage, health, and genotype.
- Existing research highlights considerable variation in Se status across populations, from deficiency to toxicity.
Purpose of the Study:
- To explore the role of nutrigenetics and nutrigenomics in understanding individual Se requirements.
- To assess the potential of advanced '-omics' technologies in determining optimal Se status.
- To address the controversy surrounding Se supplementation efficacy.
Main Methods:
- Leveraging advances in systems biology, genetics, and genomics (including genetic, epigenetic, transcriptomic, proteomic, and metabolomic data).
- Investigating gene variants within selenoprotein pathways and their interaction with dietary Se intake and serum levels.
- Utilizing new online resources for nutrigenetics and nutrigenomics methodologies.
Main Results:
- Nutrigenetic studies indicate that optimal dietary Se intake is highly individualized due to genetic variations in selenoproteins.
- Systems biology approaches integrating multi-omics data offer a comprehensive view of Se's biological activity.
- These approaches show promise for developing sensitive biomarkers for optimal Se status.
Conclusions:
- Personalized Se requirements necessitate a shift from one-size-fits-all recommendations towards individualized approaches.
- Nutrigenomic strategies are emerging as essential tools for optimizing Se and other micronutrient intake for individual and population health.
- Large-scale, collaborative studies with standardized designs and innovative data analysis are crucial for validating these findings and guiding public health recommendations.