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Published on: March 6, 2018
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Zinc in Prostate Health and Disease: A Mini Review.
1Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Biomedicines
|December 23, 2022
Summary
Zinc (Zn) plays a crucial role in prostate health by maintaining citrate levels. Zn deficiency is linked to prostate cancer, suggesting its potential as a biomarker for improved screening and management.
Area of Science:
- Oncology
- Biochemistry
- Urology
Background:
- Prostate cancer has high global prevalence and mortality rates, necessitating improved clinical practices.
- Zinc (Zn) is increasingly recognized for its significant role in prostate health and disease.
- Understanding Zn's influence can enhance prostate cancer outcomes.
Purpose of the Study:
- To review the multifaceted role of Zinc (Zn) in prostate health and disease.
- To explore Zn's potential as a biomarker for prostate cancer screening, prognosis, and management.
Main Methods:
- A comprehensive literature review was conducted using PubMed.
- Information on Zn in general biology and its specific involvement in prostate health and disease was gathered.
Main Results:
- Zinc (Zn) is vital for maintaining healthy prostate citrate levels.
- Zn deficiencies are observed in serum, hair, and prostate tissue of men with prostate cancer.
- Zn transporters, Zn finger proteins, matrix metalloproteinases, and Zn signaling pathways are associated with prostate cancer outcomes.
Conclusions:
- Zn's influence on prostate health and disease is complex and multidimensional.
- Personalized Zn requirements may be beneficial for prostate health.
- Further research into Zn's associations can improve prostate cancer screening, prognosis, and management strategies.
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