Related Experiment Video
Updated: May 25, 2026
03:40
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
Published on: December 20, 2024
Atopic dermatitis and allergic rhinitis--do co-effects in therapy exist?
Karsten Weller1, Stephanie Soost, Margitta Worm
1Allergy Center Charité, Department of Dermatology, Venereology and Allergology, Charité-University Medicine, Charitéplatz 1, Berlin, Germany. karsten.weller@charite.de
Summary
Patients with atopic dermatitis and allergic rhinitis may benefit from treatments targeting both conditions. Specific immunotherapy and H(1)-antihistamines show potential therapeutic co-effects for these common allergic diseases.
Area of Science:
- Immunology
- Dermatology
- Allergology
Background:
- Atopic dermatitis and allergic rhinitis often co-occur in patients.
- The complex pathogenesis of these atopic diseases is not fully understood.
- Pathophysiological overlaps suggest potential for shared therapeutic benefits.
Purpose of the Study:
- To investigate potential therapeutic co-effects in patients with co-existing atopic dermatitis and allergic rhinitis.
- To review current evidence on treatments for these related conditions.
Main Methods:
- Literature review of studies on allergen elimination, specific immunotherapy, and H(1)-antihistamines.
- Analysis of existing data on treatment efficacy in patients with both atopic dermatitis and allergic rhinitis.
Main Results:
- Limited evidence supports allergen elimination for both conditions simultaneously.
- Increasing evidence suggests beneficial effects of specific immunotherapy for atopic dermatitis patients with type I allergies.
- H(1)-antihistamines show moderate positive effects on atopic dermatitis symptoms in some studies.
Conclusions:
- A limited therapeutic co-effect can be anticipated for treatments in patients with co-existing atopic dermatitis and allergic rhinitis.
- Further research is needed to confirm these co-effects and improve treatment strategies.
- A deeper understanding of the pathophysiology will aid in treating atopic manifestations.
Related Concept Videos
01:17Drugs Used in Lower Respiratory Disorders: Overview
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
01:30Allergic Reactions: Anaphylaxis
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
01:27Allergic Drug Reactions
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
01:16Drugs Used in Upper Respiratory Disorders: Overview
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...