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Invasive pneumococcal pneumonia and respiratory virus co-infections

Hong Zhou1, Michael Haber, Susan Ray

  • 1Emory University, Atlanta, Georgia 30322, USA.

Emerging Infectious Diseases
|February 7, 2012
PubMed

Insights

Respiratory virus infections, like influenza and respiratory syncytial virus, can increase the risk of invasive pneumococcal pneumonia. This risk was particularly notable during seasons when the H3N2 influenza A strain was prevalent.

Area of Science:

  • * Epidemiology
  • * Infectious Diseases
  • * Public Health

Background:

  • * Invasive pneumococcal pneumonia (IPP) is a significant cause of morbidity and mortality.
  • * Respiratory virus infections are common and can predispose individuals to secondary bacterial infections.

Purpose of the Study:

  • * To investigate the association between respiratory virus infections and the risk of developing invasive pneumococcal pneumonia.
  • * To determine if specific respiratory viruses or influenza strains influence this association.

Main Methods:

  • * Retrospective analysis of data from 11 influenza seasons in the United States (1994-2005).
  • * Examination of the correlation between periods of high influenza and respiratory syncytial virus activity and the incidence of invasive pneumococcal pneumonia.

Main Results:

  • * Invasive pneumococcal pneumonia showed a significant association with both influenza and respiratory syncytial virus activity during 5 of the 11 seasons studied.
  • * The strength of this association was more pronounced when the H3N2 strain was the dominant influenza A virus.

Conclusions:

  • * Respiratory virus infections, particularly influenza and RSV, are linked to an increased susceptibility to invasive pneumococcal pneumonia.
  • * The specific circulating influenza A strain, such as H3N2, may modulate the risk of secondary pneumococcal infections.

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