Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Toxidromes: Clinical Features01:30

Toxidromes: Clinical Features

Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
Cytotoxic Edema: Pathophysiology01:21

Cytotoxic Edema: Pathophysiology

Cytotoxic edema is a form of cerebral edema characterized by intracellular swelling of neurons, astrocytes, and other glial cells. It develops when the mechanisms responsible for maintaining ionic gradients across the cell membrane become impaired. Under normal physiological conditions, the sodium–potassium ATPase actively transports sodium ions out of the cell and potassium ions into the cell, preserving osmotic balance and enabling electrical signaling. This pump requires a continuous supply...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthma.

The Journal of allergy and clinical immunology·2015
Same author

Fractional exhaled nitric oxide change in pediatric patients after emergency department care of asthma exacerbations.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2014
Same author

Exhaled nitric oxide is associated with severity of pediatric acute asthma exacerbations.

The journal of allergy and clinical immunology. In practice·2014
Same author

Anaphylaxis, urticaria, and angioedema.

Pediatrics in review·2013
Same author

Retropharyngeal edema: an unusual manifestation of Kawasaki disease.

The Journal of emergency medicine·2009

Related Experiment Video

Updated: May 25, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Emergency department death from systemic loxoscelism.

Jessica L Rosen1, Jon K Dumitru, Emily W Langley

  • 1Vanderbilt University Medical Center, Department of Emergency Medicine, Nashville, TN, USA.

Annals of Emergency Medicine
|February 7, 2012
PubMed
Summary

Systemic loxoscelism from a brown recluse spider bite can be fatal. This report details a rare case of rapid death following envenomation and discusses current management strategies.

Related Experiment Videos

Last Updated: May 25, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Area of Science:

  • Toxicology
  • Arachnology

Background:

  • Systemic loxoscelism is a severe illness caused by the brown recluse spider (Loxosceles reclusa) venom.
  • Envenomation can lead to serious complications including hemolysis, acute renal failure, and disseminated intravascular coagulation.

Observation:

  • This report describes an exceptionally rapid fatality due to systemic loxoscelism.
  • Death occurred in less than 24 hours post-envenomation.

Findings:

  • The case highlights the potential for rapid and lethal progression of systemic loxoscelism.
  • Early recognition and intervention are critical in managing severe brown recluse spider bites.

Implications:

  • This case underscores the importance of prompt medical evaluation for suspected brown recluse spider bites.
  • The findings support the need for refined screening algorithms and timely therapeutic approaches for systemic loxoscelism.