Search research articles

Related Concept Videos

Diabetic Neuropathy

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

Diabetes: Symptoms, Diagnosis, and Complications

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...

Type I Diabetes II: Pathophysiology

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

Type II Diabetes II: Pathophysiology

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

Pathophysiology of Diabetes

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...

Diabetes Mellitus: Overview and Type I Subtype

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The non-cariogenic effects of aspartame: A systematic review and meta-analysis.

Journal of dentistry·2025

Same author

A regulatory pathway model of neuropsychological disruption in Havana syndrome.

Frontiers in psychiatry·2023

Same author

Correction: Historical Review of the Use of Relative Risk Statistics in the Portrayal of the Purported Hazards of High LDL Cholesterol and the Benefits of Lipid-Lowering Therapy.

Cureus·2023

Same author

Historical Review of the Use of Relative Risk Statistics in the Portrayal of the Purported Hazards of High LDL Cholesterol and the Benefits of Lipid-Lowering Therapy.

Cureus·2023

Same author

Military Family Medicine Readiness for National Pandemic Hospital Support.

Family medicine·2022

Same author

Relation of glycemic status with unrecognized MI and the subsequent risk of mortality: The Jackson Heart Study.

American journal of preventive cardiology·2022

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 25, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Does diabetes hide osteoarthritis pain?

Paul E Leaverton¹, Jennifer Peregoy, Lissa Fahlman

¹Arthritis Research Institute of America, 300 South Duncan Ave., #188, Clearwater, FL 33755, USA. peleavert@yahoo.com

Medical Hypotheses

|February 7, 2012

Summary

This summary is machine-generated.

Diabetic neuropathy may explain why some osteoarthritis patients don't feel pain despite X-ray evidence. This condition, linked to glucose metabolism, could affect pain perception before type 2 diabetes diagnosis.

More Related Videos

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

Related Experiment Videos

Last Updated: May 25, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Fu's Subcutaneous Needling for Knee Osteoarthritis Pain

Published on: March 24, 2023

Area of Science:

Gerontology
Endocrinology
Rheumatology

Background:

Osteoarthritis (OA) diagnosis is challenged by discordance between radiographic findings and patient-reported pain.
Existing explanations for this pain-radiograph gap are insufficient for many OA patients.
Diabetic neuropathy is a highly prevalent condition, particularly in aging populations.

Purpose of the Study:

To propose and explore the hypothesis that diabetic neuropathy contributes to the underreporting of OA pain.
To investigate the potential role of glucose metabolism dysfunction in altering pain perception in OA patients.

Main Methods:

This study is theoretical, proposing a hypothesis based on existing knowledge of OA, diabetic neuropathy, and pain perception.
Future research would involve validating this association through clinical studies and quantitative analysis.

Main Results:

The hypothesis suggests that neuropathy, stemming from glucose dysmetabolism, may progressively inhibit pain sensation in affected individuals.
This pain inhibition could occur even in early stages of glucose dysmetabolism, preceding a formal diabetes diagnosis.

Conclusions:

Diabetic neuropathy offers a potential explanation for a subset of osteoarthritis patients who exhibit radiographic OA but report minimal or no pain.
Understanding this link could significantly improve OA case definitions and management strategies, especially in aging populations with high rates of diabetes and pre-diabetes.