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Pseudohyperkalaemia in thrombocythaemia.

R W Wulkan1, J J Michiels

  • 1Department of Clinical Chemistry, University Hospital Dijkzigt (Erasmus University Rotterdam).

Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Fur Klinische Chemie Und Klinische Biochemie
|July 1, 1990
PubMed
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Pseudohyperkalaemia, a false high potassium level, can occur in thrombocythaemia with high platelet counts. Potassium is released from platelets during coagulation degranulation, not aggregation.

Area of Science:

  • Hematology
  • Clinical Chemistry

Background:

  • Pseudohyperkalaemia is a common laboratory finding.
  • Thrombocythaemia is characterized by elevated platelet counts.
  • Polycythaemia vera can be associated with thrombocythaemia.

Purpose of the Study:

  • To investigate the relationship between platelet counts and serum potassium levels.
  • To determine the mechanism of potassium release from platelets.

Main Methods:

  • Correlation analysis between platelet counts and serum potassium.
  • Analysis of potassium release during platelet aggregation and degranulation.

Main Results:

  • Pseudohyperkalaemia observed in thrombocythaemia with platelet counts > 600 X 10(9)/l.

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  • A significant positive correlation (r=0.82) found between platelet count and serum potassium.
  • Potassium release occurs during platelet degranulation, not aggregation.

    • Conclusions:

    • Elevated platelet counts in thrombocythaemia can lead to pseudohyperkalaemia.
    • Platelet degranulation is the primary mechanism for potassium release in this condition.