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Updated: May 25, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
[Preparation of paeonol-beta-cyclodextrin inclusion complex loaded colon specific delivery tablets]
Tongyan Wang1, Qihua Cui, Qingri Cao
1Department of Pharmaceutics, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.
New colon-specific tablets were developed using paeonol-beta-cyclodextrin inclusion complex (Pae-beta-CYD). These tablets demonstrate controlled paeonol release in the colon, influenced by pH and enzymes.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Paeonol is a traditional Chinese medicine with various therapeutic properties.
- Developing colon-specific drug delivery systems is crucial for treating colonic diseases effectively.
Purpose of the Study:
- To formulate and characterize paeonol-beta-cyclodextrin inclusion complex (Pae-beta-CYD) loaded colon-specific release tablets.
- To optimize the formulation for controlled paeonol release in the colonic environment.
Main Methods:
- Pae-beta-CYD inclusion complex was prepared.
- Core tablets were formulated with the complex, peonidin, and calcium acetate.
- Tablets were coated with Eudragit S100 and characterized for coating weight, plasticizer amount, curing time, and temperature.
- In vitro drug release studies were conducted.
Main Results:
- Optimized formulation achieved a 5-6 hour delayed release of paeonol in pectinase or rat colon content media.
- A 12% coating weight gain and 20% Dibutyl phthalate (DBP) as plasticizer, with 12-hour curing at 45°C, were optimal conditions.
- The Pae-beta-CYD loaded tablets exhibited controlled release characteristics.
Conclusions:
- Pae-beta-CYD loaded colon-specific release tablets demonstrate pH-dependent and enzyme-dependent release properties.
- The developed formulation shows potential for targeted delivery of paeonol to the colon.
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