[When to think about lupus?]

Clinical and biological manifestations of systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease, which is characterized by the presence of autoantibodies directed against various nuclear antigens. It is typically a relapsing and remitting multi-system disease, and patients can present in many different ways. The most common manifestations include rash, arthritis and fatigue. At the other end of the spectrum, SLE can cause nephritis, various neurological manifestations, and severe cytopenia. Physicians should be aware of the vast clinical spectrum of the disease as well as of its characteristic biological features.