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Updated: May 25, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Changing the way we diagnose tuberculids with interferon gamma release assays
Hong Yi Koh1, Liang Kiat Tay, Shiu Ming Pang
1Dermatology Unit, Singapore General Hospital, Singapore. koh.hong.yi@singhealth.com.sg
Abstract:
Diagnosing tuberculids traditionally requires clinicopathological correlation together with positive tuberculin skin tests (TST) or demonstration of Mycobacterium tuberculosis (MTB) DNA by polymerase chain reaction (PCR). Interferon gamma release assays (IGRA) are new laboratory tests approved for the diagnosis of MTB infection. We describe three patients with tuberculids who had no other clinical feature of tuberculosis (TB) infection and negative PCR of skin biopsies. Their diagnoses were aided by positive IGRA.
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