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Updated: May 25, 2026
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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
DVT prophylaxis in relation to patient risk profiling - TUNE-IN study
Pieter Wessels1, Wayne Jonathan Riback
1Department of Medical Oncology, Steve Biko Hospital, Pretoria, South Africa. wesselspf@mweb.co.za
Summary
Hospitalized patients face high venous thromboembolism (VTE) risk, with clinical risk assessment differing from a modified risk assessment model (RAM). Many patients at risk for VTE do not receive adequate prophylaxis.
Area of Science:
- Medical research
- Clinical epidemiology
- Patient safety
Background:
- Venous thromboembolism (VTE) poses a significant risk to patients in acute hospital care, affecting over 50% globally.
- Despite the high risk, approximately half of at-risk patients do not receive appropriate VTE prophylaxis.
Purpose of the Study:
- To evaluate VTE prophylaxis use in South African private hospitals, comparing clinical assessment with a modified risk assessment model (RAM).
- To assess the relationship between VTE prophylaxis, patient risk profiles, and mobility post-discharge.
Main Methods:
- The TUNE-IN study enrolled 608 hospitalized patients.
- VTE risk was assessed using both clinical evaluation and a modified RAM.
- Prophylaxis adequacy and patient mobility were tracked.
Main Results:
- Clinical assessment identified 54.1% of patients at risk for VTE, while RAM identified 74.6%.
- Adequate VTE prophylaxis was administered to only 70.9% of all patients.
- Discrepancies between assessment methods suggest potential over- or under-diagnosis of VTE risk.
Conclusions:
- Findings align with global data, indicating over 50% of hospitalized patients are at VTE risk.
- Clinical risk assessment and RAM utilization showed poor correlation, impacting appropriate prophylaxis allocation.
- Individualized risk assessment, considering factors like BMI and age, is crucial for effective VTE prevention, especially in high-risk groups.
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