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Published on: September 7, 2017
The paradox of feline coronavirus pathogenesis: a review
Luciana Wanderley Myrrha1, Fernanda Miquelitto Figueira Silva, Ethel Fernandes de Oliveira Peternelli
1Laboratório de Infectologia Molecular Animal (LIMA), Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n Campus Universitário, 36570-000 Vicosa, MG, Brazil.
Abstract:
Feline coronavirus (FCoV) is an enveloped single-stranded RNA virus, of the family Coronaviridae and the order Nidovirales. FCoV is an important pathogen of wild and domestic cats and can cause a mild or apparently symptomless enteric infection, especially in kittens. FCoV is also associated with a lethal, systemic disease known as feline infectious peritonitis (FIP). Although the precise cause of FIP pathogenesis remains unclear, some hypotheses have been suggested. In this review we present results from different FCoV studies and attempt to elucidate existing theories on the pathogenesis of FCoV infection.
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