Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell spatiotemporal dissection of the human maternal-fetal interface.

Nature·2026
Same author

Intermediate Risk Rhabdomyosarcoma in Very Young Children (Less Than or Equal to 24 Months) Treated on the Prior Children's Oncology Group Protocol ARST1431.

Pediatric blood & cancer·2026
Same author

KMT2C and KMT2D amplify GRHL2-driven enhancer activation.

bioRxiv : the preprint server for biology·2026
Same author

Pseudomyogenic Hemangioendothelioma With Novel NEDD9::FOSB Fusion Gene.

Pediatric dermatology·2026
Same author

Clinical and molecular characteristics of constitutional mismatch repair deficiency syndrome: a case series of five children and appraisal of diagnostic guidelines.

Diagnostic pathology·2026
Same author

Synergy between regulatory elements can render cohesin dispensable for distal enhancer function.

Science (New York, N.Y.)·2025
Same journal

PKM and the maintenance of memory.

F1000 biology reports·2013
Same journal

Cytokines in chronic respiratory diseases.

F1000 biology reports·2013
Same journal

Protein flexibility, not disorder, is intrinsic to molecular recognition.

F1000 biology reports·2013
Same journal

The case for intrinsically disordered proteins playing contributory roles in molecular recognition without a stable 3D structure.

F1000 biology reports·2013
Same journal

Is perceptual learning associated with changes in a sensory region?

F1000 biology reports·2012
Same journal

Molecular evolution and genetics of postzygotic reproductive isolation in plants.

F1000 biology reports·2012
See all related articles

Related Experiment Video

Updated: May 25, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

microRNA induced transdifferentiation.

Archana Shenoy1, Robert Blelloch

  • 1The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Center for Reproductive Sciences Department of Urology, 35 Medical Center Way, Pod B 1018, University of California, San Francisco, San Francisco, CA. 94143 - 0667 USA.

F1000 Biology Reports
|February 8, 2012
PubMed
Summary
This summary is machine-generated.

MicroRNAs can now drive the conversion of fibroblasts to neurons, a surprising advance in transdifferentiation. This research explores microRNA-mediated cell reprogramming for potential therapeutic applications.

More Related Videos

MicroRNA Expression Profiles of Human iPS Cells, Retinal Pigment Epithelium Derived From iPS, and Fetal Retinal Pigment Epithelium
10:19

MicroRNA Expression Profiles of Human iPS Cells, Retinal Pigment Epithelium Derived From iPS, and Fetal Retinal Pigment Epithelium

Published on: June 24, 2014

Primary Cell Cultures to Study the Regeneration Potential of Murine Müller Glia after MicroRNA Treatment
10:16

Primary Cell Cultures to Study the Regeneration Potential of Murine Müller Glia after MicroRNA Treatment

Published on: March 28, 2022

Related Experiment Videos

Last Updated: May 25, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

MicroRNA Expression Profiles of Human iPS Cells, Retinal Pigment Epithelium Derived From iPS, and Fetal Retinal Pigment Epithelium
10:19

MicroRNA Expression Profiles of Human iPS Cells, Retinal Pigment Epithelium Derived From iPS, and Fetal Retinal Pigment Epithelium

Published on: June 24, 2014

Primary Cell Cultures to Study the Regeneration Potential of Murine Müller Glia after MicroRNA Treatment
10:16

Primary Cell Cultures to Study the Regeneration Potential of Murine Müller Glia after MicroRNA Treatment

Published on: March 28, 2022

Area of Science:

  • Cell biology
  • Molecular biology
  • Regenerative medicine

Background:

  • Transdifferentiation allows direct cell type conversion, offering therapeutic potential.
  • Transcription factors have been the primary drivers of induced cell reprogramming.
  • Recent findings reveal microRNAs also play a role in cell fate transitions.

Purpose of the Study:

  • To review recent advancements in microRNA-induced transdifferentiation.
  • To discuss the mechanisms behind microRNA-mediated cell reprogramming.
  • To explore the potential of microRNAs for in vitro and in vivo cell conversion.

Main Methods:

  • Literature review of transdifferentiation studies.
  • Analysis of mechanisms involving microRNAs in cell reprogramming.
  • Discussion of experimental evidence for microRNA-driven cell fate changes.

Main Results:

  • MicroRNAs, not just transcription factors, can induce transdifferentiation.
  • MicroRNAs alone have demonstrated the ability to convert fibroblasts to neuron-like cells.
  • Efficiency of microRNA-induced transdifferentiation is currently low but promising.

Conclusions:

  • MicroRNA-induced transdifferentiation is a rapidly evolving field.
  • Understanding microRNA mechanisms is key to improving reprogramming efficiency.
  • MicroRNAs hold potential for versatile cell type conversion in research and therapy.