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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

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Related Experiment Video

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Mouse Models for Graft Arteriosclerosis
07:37

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Published on: May 14, 2013

Mouse models of atherosclerosis.

E Maganto-Garcia1, M Tarrio1, A H Lichtman1

  • 1Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Current Protocols in Immunology
|February 9, 2012
PubMed
Summary
This summary is machine-generated.

Genetically modified mice on high-fat diets are key for studying atherosclerosis. This review covers mouse models, diets, and methods to analyze lipid deposition, lesion size, and immune cell presence in arteries.

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Area of Science:

  • Cardiovascular Research
  • Immunology
  • Metabolic Disorders

Background:

  • Atherosclerosis research heavily relies on genetically modified mouse models.
  • These models often require specific diets to induce disease phenotypes like hypercholesterolemia.
  • Understanding immune system and lipid metabolism interactions is crucial for atherosclerosis pathogenesis.

Purpose of the Study:

  • To review current mouse models used in atherosclerosis research.
  • To discuss various dietary strategies employed to induce atherosclerosis in these models.
  • To outline techniques for quantifying lipid deposition, lesion size, and immune cell infiltration in arterial walls.

Main Methods:

  • Review of literature on genetically altered mice relevant to atherosclerosis.
  • Analysis of dietary interventions, particularly high-cholesterol and high-fat diets.
  • Description of histological and imaging techniques for assessing atherosclerotic lesions.
  • Methods for immunophenotyping and quantifying immune cells within lesions.

Main Results:

  • A variety of genetically modified mouse models exist for studying atherosclerosis.
  • High-fat, high-cholesterol diets effectively induce hypercholesterolemia and arterial lesions in susceptible mice.
  • Established methods allow for quantitative assessment of lipid deposition, lesion progression, and immune cell involvement.

Conclusions:

  • Genetically modified mice and specific diets are indispensable tools for atherosclerosis research.
  • Standardized methods for lesion and immune cell analysis are vital for reproducible results.
  • This review provides a comprehensive overview of current methodologies in the field.