Related Experiment Video
Updated: May 25, 2026

05:32
In Vitro Chemical Mapping of G-Quadruplex DNA Structures by Bis-3-Chloropiperidines
Published on: May 12, 2023
Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β
Brian T Chamberlain1, Vinod K Batra, William A Beard
1Departments of Chemistry and Biology, University of Southern California, Los Angeles, CA 90089, USA.
Chembiochem : a European Journal of Chemical Biology
|February 9, 2012
Abstract:
The influence of water: crystallization of (R/S)-α,β-CHF-dATP with the preorganized pol β-DNA complex shows that (S)-α,β-CHF-dATP is preferentially bound to the active site with the C=F fluorine proximal to a structural water bound to Asp276.

