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Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

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Related Experiment Video

Updated: May 25, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Stem cells and lung diseases.

S Singhal1, S Achary, S Mahajan

  • 1Dept. of Chest & Tuberculosis, AVBRH, DMIMS, Sawangi (M), Wardha, Maharashtra.

The Journal of the Association of Physicians of India
|February 10, 2012
PubMed
Summary
This summary is machine-generated.

Stem and progenitor cells, including endothelial progenitor cells (EPCs) and mesenchymal stem cells (MSCs), are crucial for lung repair and treating lung diseases. Research explores cell therapies and bioengineering for regenerative medicine.

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Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs
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Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs

Published on: June 17, 2016

Related Experiment Videos

Last Updated: May 25, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs
09:47

Isolation of CD146+ Resident Lung Mesenchymal Stromal Cells from Rat Lungs

Published on: June 17, 2016

Area of Science:

  • Regenerative Medicine
  • Pulmonary Research
  • Cell Biology

Background:

  • Lung injury and diseases involve complex repair mechanisms.
  • Stem and progenitor cells are increasingly recognized for their roles in tissue regeneration.
  • Current cell therapy approaches for lung conditions are under active investigation.

Purpose of the Study:

  • To review the role of stem and progenitor cells in lung repair after injury.
  • To assess the current status of cell therapy for lung diseases.
  • To highlight emerging research in lung tissue bioengineering.

Main Methods:

  • Literature review of stem and progenitor cell functions in lung injury and repair.
  • Analysis of current cell therapy strategies for pulmonary diseases.
  • Examination of novel bioengineering and 3D culture techniques.

Main Results:

  • Circulating endothelial progenitor cells (EPCs) are involved in acute and fibrotic lung injuries.
  • Fibrocytes contribute to fibrotic lung disease pathology, presenting a therapeutic target.
  • Mesenchymal stem cells (MSCs) demonstrate anti-inflammatory and injury-suppressing effects in lung disease models.

Conclusions:

  • Stem and progenitor cells, including EPCs, fibrocytes, and MSCs, are vital for lung repair and disease modulation.
  • Cell therapy holds promise for treating various lung diseases.
  • Bioengineering and ex vivo lung tissue generation represent future directions in regenerative pulmonology.