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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

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Propylene glycol intoxication in a dog.

Melissa A Claus¹, Karl E Jandrey, Robert H Poppenga

¹Veterinary Medical Teaching Hospital, University of California Davis, Davis, CA 95616, USA. dr.claus@gmail.com

Journal of Veterinary Emergency and Critical Care (San Antonio, Tex. : 2001)

|February 10, 2012

Summary

This case study details the first documented instance of propylene glycol intoxication in a dog. Hemodialysis proved effective in treating the condition, leading to a full recovery.

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Area of Science:

Veterinary Toxicology
Small Animal Internal Medicine

Background:

Propylene glycol (PG) is a common industrial solvent and antifreeze, but its toxic effects in dogs are not well-documented.
Ethylene glycol (EG) intoxication is a common emergency in dogs, and initial diagnostic tests may yield false positives.

Observation:

An Australian cattle dog presented with ataxia and disorientation after unsupervised roaming at a construction site.
Initial point-of-care testing suggested ethylene glycol intoxication, prompting treatment with ethanol and hemodialysis.
Laboratory analysis confirmed high levels of propylene glycol and ruled out ethylene glycol.

Findings:

The dog exhibited clinical signs consistent with propylene glycol toxicity.
Hemodialysis effectively cleared propylene glycol from the dog's system.
The dog recovered fully following treatment.

Implications:

This report highlights the potential for propylene glycol intoxication in dogs, particularly after exposure to industrial sites.
Hemodialysis is presented as a viable and effective treatment modality for canine propylene glycol toxicity.
Veterinarians should consider propylene glycol toxicity in differential diagnoses for dogs presenting with signs of glycol intoxication, even with initial positive ethylene glycol tests.