Measuring the forces acting during microtomy by the use of load cells

The forces acting upon the cutting blade during microtomy can be accurately measured by using a load cell. From the information obtained, the optimal knife angles (rake, clearance and slant) can be determined. In addition, the speed of cutting and thickness of sections can also be optimized. The information obtained from the load cell additionally reveals variations in tissue composition which affect the cutting forces. This paper is a preliminary communication to illustrate the possible roles for a modified microtome in (a) the study of microtomy and (b) comparative studies of tissue density.