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Updated: May 25, 2026

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Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
Published on: May 2, 2025
PD-L1 co-stimulation, ligand-induced TCR down-modulation and anti-tumor immunotherapy
Katarzyna Karwacz1, Frederick Arce, Christopher Bricogne
1Center for Neurologic Disease; Harvard Medical School; Boston, MA USA.
Oncoimmunology
|February 10, 2012
Abstract:
PD-1 engagement on the surface of effector T cells strongly suppresses their cytotoxic function, which constitutes a major obstacle for T cell-mediated anti-tumor activities. Surprisingly, PD-1 is strongly upregulated in T cells, engaging its ligand PD-L1 during antigen presentation. However, our recent published data may provide an explanation for this apparent contradiction.
