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Lymphotoxin and the amazing technicolor circus of intestinal homeostasis

J L Browning1

  • 1Department of Immunobiology, Biogen Idec, Cambridge, Massachusetts, USA. jeff.browning@biogenidec.com

Mucosal Immunology
|February 10, 2012
PubMed

Recently a new lymphocyte subset called innate lymphoid cells has emerged and it includes key producers of interleukin (IL)-17 and IL-22 in the mucosal environment. Using Citrobacter rodentium infection to deliver a pathogenic insult to the colon, two studies have revealed an underlying role for lymphotoxin-β receptor signaling in the generation of IL-22 by these cells. This observation links a system well known for its ability to organize lymphoid microenvironments into a basic mucosal response.

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