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Related Experiment Videos

Triamterene nephrolithiasis: renewed attention is warranted.

M C Carr1, E L Prien, R K Babayan

  • 1Department of Urology, Boston University Medical Center, Massachusetts.

The Journal of Urology
|December 1, 1990
PubMed
Summary

Triamterene, a diuretic, may cause urinary stones more often than previously thought. This study found an increasing number of triamterene stones, highlighting the need for greater awareness of this medication side effect.

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Area of Science:

  • Nephrology
  • Urology
  • Pharmacology

Background:

  • Triamterene is a potassium-sparing diuretic.
  • Triamterene has been associated with urinary calculus formation, but this was considered rare.
  • Recent observations suggest a potential underestimation of this risk.

Purpose of the Study:

  • To investigate the incidence of triamterene-related urinary stones.
  • To assess if the phenomenon is as rare as presumed.
  • To re-emphasize the calculogenic potential of triamterene.

Main Methods:

  • Retrospective review of urinary stone analyses.
  • Analysis of stones collected over a ten-year period.
  • Utilizing data from a single, accredited stone analysis laboratory.

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Main Results:

  • An increasing trend in the occurrence of triamterene stones was observed over the decade.
  • The data challenges the presumption that triamterene-induced urolithiasis is a rare event.
  • Specific stone composition analysis confirmed the presence of triamterene.

Conclusions:

  • The incidence of triamterene stones appears to be rising.
  • Increased clinical awareness regarding the lithogenic risk of triamterene is warranted.
  • Healthcare providers should consider this risk when prescribing triamterene-containing medications.