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Bilateral cataract in a cynomolgus monkey.

Yuji Sasaki1, Rinya Kodama, Shuichiro Iwashige

  • 1Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., 2438 Miyanoura, Kagoshima 891-1394, Japan.

Journal of Toxicologic Pathology
|February 10, 2012
PubMed
Summary

A rare case of severe, spontaneous, bilateral cataract in a 7-year-old cynomolgus monkey is detailed. Histopathology revealed significant lens fiber excavation and epithelial cell changes, offering insights into primate ocular pathology.

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Area of Science:

  • Veterinary Ophthalmology
  • Primate Pathology

Background:

  • Cataracts are a common cause of vision impairment in various species.
  • Spontaneous, severe cataracts in non-human primates like cynomolgus monkeys are infrequently reported.

Purpose of the Study:

  • To document and characterize a rare case of spontaneous, bilateral, hypermature cataract in a cynomolgus monkey.
  • To investigate the histopathological and immunohistochemical features of the observed cataract.

Main Methods:

  • Macroscopic examination of the eyes.
  • Histopathological analysis of lens tissue.
  • Immunohistochemical staining for vimentin, cytokeratin, and alpha-smooth muscle actin (α-SMA).

Main Results:

  • Severe lens opacity and thinning observed macroscopically.
Keywords:
cynomolgus monkeyhistopathologyhypermature cataracts

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  • Histopathology showed lens fiber excavation, swelling, distortion, and epithelial cell atrophy.
  • Proliferation of spindle cells expressing vimentin, cytokeratin, and α-SMA beneath the anterior capsule.

    • Conclusions:

    • The observed spindle cells are likely of lens epithelial cell origin, indicating metaplasia.
    • This case highlights a rare spontaneous cataract presentation in a cynomolgus monkey.
    • Provides valuable data for understanding primate ocular diseases.