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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
[Faecal calprotectin in inflammatory bowel disease]
Taina Sipponen1, Kaija-Leena Kolho
1HYKS, Meilahden Sairaala, Gastroenterologian Klinikka.
Faecal calprotectin, a marker from leukocytes, is useful for diagnosing and monitoring inflammatory bowel diseases in adults and children. Elevated levels predict disease flares, especially in ulcerative colitis and Crohn's disease colitis.
Area of Science:
- Biochemistry
- Immunology
- Gastroenterology
Context:
- Inflammatory bowel diseases (IBD) diagnosis and monitoring.
- Faecal calprotectin as a non-invasive biomarker.
- Application across pediatric and adult populations.
Purpose:
- To highlight the utility of faecal calprotectin in IBD diagnostics.
- To discuss its role in monitoring disease activity.
- To emphasize its predictive value for disease exacerbation.
Summary:
- Calprotectin, released from neutrophilic leukocytes during intestinal inflammation, is measurable in feces.
- Faecal calprotectin serves as a valuable marker for diagnosing and monitoring IBD in both children and adults.
- High levels indicate active IBD, and elevated levels in asymptomatic individuals can predict future disease flares, particularly in ulcerative colitis and Crohn's disease colitis.
Impact:
- Facilitates earlier diagnosis and more effective management of IBD.
- Reduces the need for invasive procedures in IBD assessment.
- Improves patient outcomes through proactive monitoring and intervention for potential flares.
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