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A pilot study aimed at finding a suitable eugenol concentration for a leave-on product for use in a repeated open
Cecilia Svedman1, Malin Engfeldt, Anne Marie Api
1Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, 205 02 Malmö, Sweden. Cecilia.Svedman@skane.se
Background:
Knowledge of sensitization and elicitation thresholds and the time-dose relationship for elicitation of contact dermatitis is important in order to provide safe products for consumers.
Objective:
Since previous studies performed with eugenol had showed negative results in a repeat open application study (ROAT) study, we wanted to perform a ROAT with higher concentration (maximum allowed) and longer ROAT.
Materials:
5 volunteers previously tested positive to eugenol were studied. They performed a ROAT test for maximum 4 weeks with four different solutions. Results. Four of five reacted to the maximum concentration of eugenol in the ROAT.
Conclusion:
In patients sensitized to eugenol, with the maximum allowed concentration of eugenol and given a prolonged ROAT (4 weeks), there is a clear risk of elicitating an allergic contact dermatitis.
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